Dental treatments utilize the instruments those generate aerosol comprise of blood and saliva which able to spread the microbial among dental staffs and also the patients. The quality assurance of the air in dental clinic is crucial in control of the infection. This articles will explain how dental aerosol generate during dental treatment, methods of air microbial sample collection, index of microbial air contamination as well as strategies to reduce or eliminate the aerosol. The proper management of air in dental clinic is not only provide the safe working environment for dental staffs but also provide safety for the dental patients.