Periodontal disease is one of the major health problem impacted the quality of human life and associated with systemic diseases. A number of antiplaque agents and antibiotics have been used as an adjunctive treatment for periodontal therapy. However, the use of these agents might increase bacterial resistance and unwanted side effects. Herbs are important sources of new drug development. Some herbs have been used for century in traditional medicine. This literature will provide the research information about Thai medicinal plants that have potential to be the candidates for development of anti-plaque and anti-periodontal agents in the future.