The efficacy of an herbal-based toothpaste on the control of plaque and gingivitis was investigated in a double-blind study on 40 subjects aged 22-54 years. Over a period of 8 weeks, 20 subjects used either control or preparations containing herbal ingredients. Parameters measured were the plaque, gingival and bleeding indices. These examinations were determined at baseline, 2, 4, 6 and 8 weeks. The test and control toothpastes significantly reduced all parameters measured in comparison to the baseline values (p<0.0001) at all trial periods. In the present study, the herbal toothpaste was no more effective than the control toothpaste in reducing plaque and gingival inflammation. The test toothpaste exhibited slightly lower number of plaque, gingival and bleeding indices than the control toothpaste at all trial periods, but the differences were not statistically significant. Thus, the present results did not demonstrate a significant clinical advantage of the herbal-based toothpaste over the control toothpaste.The efficacy of an herbal-based toothpaste on the control of plaque and gingivitis was investigated in a double-blind study on 40 subjects aged 22-54 years. Over a period of 8 weeks, 20 subjects used either control or preparations containing herbal ingredients. Parameters measured were the plaque, gingival and bleeding indices. These examinations were determined at baseline, 2, 4, 6 and 8 weeks. The test and control toothpastes significantly reduced all parameters measured in comparison to the baseline values (p<0.0001) at all trial periods. In the present study, the herbal toothpaste was no more effective than the control toothpaste in reducing plaque and gingival inflammation. The test toothpaste exhibited slightly lower number of plaque, gingival and bleeding indices than the control toothpaste at all trial periods, but the differences were not statistically significant. Thus, the present results did not demonstrate a significant clinical advantage of the herbal-based toothpaste over the control toothpaste.