A new calcium silicate-based cement, Biodentine™ (Septodont, Saint Maur des Fosses, France), has recently been introduced. With its biocompatibility and dentinal bridge-promoting properties comparable to those of the clinically well-accepted mineral trioxide aggregate (MTA), Biodentine™ could probably be an appropriate option for pulp capping procedures. However, clinical outcome studies on Biodentine™ are limited. Moreover, vital pulp therapy in cariously exposed permanent teeth is also controversial. These case reports describe clinical procedures and outcomes of partial pulpotomy using Biodentine™ as a pulp capping material in four cariously exposed adult permanent teeth in three patients aged 22 to 50 years. At 12 to 30 months follow-up, none of the patients experienced spontaneous pain, swelling or abscess formation. All teeth displayed a positive response to pulp testing and functioned normally. The radiographic evaluation revealed normal periapical areas.