The aim of mandibular reconstruction, after trauma or ablative tumor surgery, is to restore masticatory function, deglutition, phonation, and facial esthetics. Nowadays, free vascularized bone grafts with microvascular reconstructive surgery have become the preferred method for mandibular reconstruction.
This is the first case report of the Faculty of Dentistry, Chulalongkorn University that used the osteomyocutaneous fibular free flap with the microvascular surgery reconstruction for the large intraoral soft tissue and mandibular bone defects after resection of recurrent ameloblastoma in which a reconstruction with non-vascularized bone graft was not possible. At one-year follow up, the patient was free of disease with normal facial contour, demonstrated normal mandibular function and proper oral mucosa for denture substitution.