This study aims to measure the fracture strength in molar region of new zirconia-reinforced lithium silicate (Celtra™ Duo, Dentsply) in comparison to lithium disilicate all-ceramic crowns (IPS e.max^® CAD, Ivoclar Vivadent) made with computer-aided design/computer-aided manufacturing. Thirty standardized crown resin models were prepared with the same dimensions and randomly assigned to either Celtra™ Duo or IPS e.max^® CAD group, fifteen each. Fractural load values were measured by a universal testing machine (Instron model 4464, USA) with a static load applied along the long axis of the specimen at a crosshead speed of 1 mm/min at room temperature until fracture. Fracture load values were recorded for each specimen and statistically analyzed by using unpaired t-test. The mean ± SD for the fracture load values were 1,696.67 ± 230.31 N and 1,569.87 ± 154.71 N for Celtra™ Duo and IPS e.max^® CAD, respectively. There was no statistically differences of fracture strength between Celtra™ Duo and IPS e.max^® CAD (p < 0.05).