There are numerous clinical studies in various antimicrobial agents improving the clinical outcome of chronic periodontitis therapy in smokers. Smokers with chronic periodontitis do not tend to respond to the periodontal therapy as favorable as non-smokers. The aim of this study was to compare the clinical results of one-visit full-mouth scaling and root planing with and without the use of azithromycin in smokers. 28 smokers with chronic periodontitis were divided equally into 2 groups, control group and test group. All clinical data were recorded; probing pocket depth, clinical attachment level, full mouth bleeding on probing and full mouth plaque index at 3 months and 6 months follow-up. The probing pocket depth and clinical attachment level were subdivided into 3 groups according to initial probing pocket depth as follows; 1-3, 4-6 and >7 mm, respectively. At 3 and 6 months, both therapies resulted in significant improvement when compared to baseline of probing pocket depth, clinical attachment level, full mouth bleeding on probing and full mouth plaque index. At 3 and 6 months, the clinical improvement in probing pocket depth and clinical attachment level in subgroup of initial pocket depth >7 mm. were significantly better in full-mouth periodontal therapy
with the use of azithromycin. In conclusion, the use of azithromycin as an adjunct to full-mouth periodontal therapy demonstrates favorable results in probing pocket depth reduction and clinical attachment level gain in smokers with advanced chronic periodontitis.