Nowadays, there are increasing number of periodontitis patients seeking orthodontic treatment due to problems of malocclusion or unesthetics. There have been some concerns giving orthodontic treatment in periodontitis patients than normal patient because of the inflammation and reduction of periodontium. Therefore, the orthodontists should know about background of disease, relationship of malocclusion and periodontitis and limitation of orthodontic treatment. This article focus on how to prepare and maintain healthy periodontium before, during and after orthodontic treatment including periodontal surgery especially guided tissue regeneration. Moreover, this article introduces the interrelationship of multidisciplinary team such as orthodontist, periodontist and general dentist.