Orthodontic treatment aims to enhance dental aesthetics and functionality. Its impact on masticatory performance, which encompasses the efficiency and effectiveness of chewing, remains an important area of study. Factors influencing masticatory performance include dental alignment, occlusal contact, and muscular coordination. This review aims to summarize both the relationship between masticatory performance after orthodontic treatment and the commonly used methods for measuring masticatory performance following orthodontic treatment. A systematic search of electronic databases (PubMed [including MEDLINE] and Scopus) was conducted for studies published from January 2000 up to May 2024, focusing on masticatory performance in patients undergoing orthodontic treatment. Studies were selected based on predefined eligibility criteria, data on study characteristics, orthodontic interventions, masticatory assessment methods, and key findings regarding masticatory changes that were extracted. Out of 797 records identified, 13 studies met the inclusion criteria. These studies evaluated masticatory performance before and after orthodontic treatment using both subjective and objective measurements, with maximum bite force and occlusal contact area being the most used methods. The review found that non-extraction orthodontic treatment generally improved masticatory performance, as evidenced by comminution tests and self-reported ability, although performance still lagged behind natural occlusion post-treatment. Extraction orthodontic treatment presented mixed results, with lower masticatory performance in the early retention phase that gradually increased, ultimately showing no significant differences in occlusal contact area or force between extraction and non-extraction groups over time. Orthognathic surgery enhanced masticatory function, but it still did not reach the levels observed in individuals with natural occlusion, despite improvements in bite force and occlusal contact area over time. Overall, non-extraction treatment showed improvements but remained inferior to controls, while extraction treatment had variable outcomes and orthognathic surgery improved function but fell short of natural occlusion.